Researchers from the Child Health Research Institute, the School of Medicine, University of Missouri, Columbia, MO, (USA), the Translational Research Unit, Instituto de Investigación Sanitaria de Aragón (Spain), and the Hospital Universitario Miguel Servet, Zaragoza, (Spain) published an article in early 2022 showing that Epigenetic age acceleration in obstructive sleep apnea is reversible with the right treatment.
Obstructive Sleep Apnea (OSA) causes oxidative stress and systemic inflammatory pathways to become activated and spread, effectively simulating accelerated biological ageing (senescence).
The complex and time-dependent decline of physiological functions that comes with biological ageing is accompanied by illness and mortality.
Epigenetic changes appear with ageing in a continuous and accelerated accumulation that can either be systemic or limited to a particular tissue or cell type. DNA methylation clocks, also known as epigenetic clocks, have become effective biological age prediction techniques.
Epigenetic clocks can evaluate if biological age acceleration occurs in certain disorders or in response to environmental conditions by regressing DNA methylation age on chronological age.
Age acceleration assessments in blood using this method were abnormally high in the presence of prevalent disorders such obesity, neurological illnesses, and smoking.